Commercial Safety Testing

In Vitro Safety Testing for Cosmetics, Consumer Products and Industrial Chemicals

CBT supports cosmetics and consumer product companies (and chemical industry) with human-relevant, non-animal safety testing aligned with current regulatory expectations, including MOCRA.
Our platforms use 3D reconstructed human tissues that closely mimic in vivo physiology, enabling reliable and predictive safety assessment without animal testing.

Our Capabilities

3D Human Skin Models

Using 3D reconstructed human epidermis (RhE):

Skin irritation and corrosion
Barrier function and toxicity
Repeat exposure studies

Scientific basis:

Multi-layered keratinocyte cultures replicate the stratum corneum barrier, enabling accurate prediction of irritation and corrosion responses.

OECD Guidelines:

Skin Irritation: OECD TG 439
Skin Corrosion: OECD TG 431

Using 3D reconstructed human corneal epithelium (RhCE):

Eye irritation assessment using validated in vitro systems
Alternatives to animal testing

Scientific basis:

Stratified corneal epithelial cells reproduce ocular surface responses, allowing prediction of irritation potential through viability and barrier disruption endpoints.

OECD Guideline:

Eye Irritation: OECD TG 492

Inhalation Toxicity (In Vitro)

Using 3D reconstructed human airway / respiratory tissues:

Aerosols, sprays, and volatile compounds
Respiratory exposure assessment

Scientific basis:

Air–liquid interface cultures of bronchial epithelial cells mimic respiratory tract architecture and exposure conditions, enabling realistic aerosol and vapor testing.

Scientific Validation

Our in vitro models are supported by data presented at the Society of Toxicology (SOT), demonstrating their predictive performance and applicability to real-world safety assessment.

Key highlights: