In Vitro Safety Testing for Cosmetics, Consumer Products and Industrial Chemicals
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CBT supports cosmetics and consumer product companies (and chemical industry) with human-relevant, non-animal safety testing aligned with current regulatory expectations, including MOCRA.
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Our platforms use 3D reconstructed human tissues that closely mimic in vivo physiology, enabling reliable and predictive safety assessment without animal testing.
Our Capabilities
3D Human Skin Models
Using 3D reconstructed human epidermis (RhE):
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Skin irritation and corrosion
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Barrier function and toxicity
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Repeat exposure studies
Scientific basis:
Multi-layered keratinocyte cultures replicate the stratum corneum barrier, enabling accurate prediction of irritation and corrosion responses.
OECD Guidelines:
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Skin Irritation: OECD TG 439
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Skin Corrosion: OECD TG 431
Using 3D reconstructed human corneal epithelium (RhCE):
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Eye irritation assessment using validated in vitro systems
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Alternatives to animal testing
Scientific basis:
Stratified corneal epithelial cells reproduce ocular surface responses, allowing prediction of irritation potential through viability and barrier disruption endpoints.
OECD Guideline:
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Eye Irritation: OECD TG 492
Inhalation Toxicity (In Vitro)
Using 3D reconstructed human airway / respiratory tissues:
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Aerosols, sprays, and volatile compounds
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Respiratory exposure assessment
Scientific basis:
Air–liquid interface cultures of bronchial epithelial cells mimic respiratory tract architecture and exposure conditions, enabling realistic aerosol and vapor testing.
Scientific Validation
Our in vitro models are supported by data presented at the Society of Toxicology (SOT), demonstrating their predictive performance and applicability to real-world safety assessment.
See Scientific Posters:
📄Inhalation Toxicity Poster (SOT-2026)
📄Skin & Eye Irritation Poster (SOT-2025)
Key highlights:
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Skin & ocular models:
Validated using OECD TG 439 and TG 492 with demonstrated reliability in irritation classification
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Inhalation models:
Novel approach developed to correlate in vitro airway exposure with real-world occupational inhalation scenarios
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Robust assay performance:
Validated methods addressing common challenges such as test article interference and assay sensitivity
OECD Status:
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Studies conducted using advanced, scientifically validated in vitro approaches
Applications
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Cosmetic ingredient and industrial chemicals safety evaluation
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Finished product safety testing
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Regulatory support (MOCRA-aligned safety substantiation)
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Product development and formulation screening
Why Work With CBT
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Human-relevant testing using 3D reconstructed human tissues
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OECD-aligned methods where applicable
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Fast turnaround and flexible study design
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Experience supporting regulatory submissions
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Integrated analytical and toxicology capabilities
