Analytical & Bioanalytical
Extracellular Vesicle Research Services
CBT helps academic, clinical and biotechnology teams turn complex biological samples into interpretable extracellular vesicle data.
- Isolation
- Characterization
- Molecular Profiling
- Functional Analysis
Services are designed around the biological question, sample limitations and the decision the study must support.
- Research-grade workflows
- MISEV-aligned reporting
- Custom assay development
Core Capabilities
Clients may begin with a focused pilot or combine services into a complete sample-to-answer program.
| Capability | What CBT provides |
|---|---|
| Isolation across sample types | Workflows for plasma, serum, urine, conditioned media and other research matrices, with recovery and contamination controls built in. |
| Physical characterization | Particle concentration, size distribution, morphology and orthogonal confirmation selected for the scientific question. |
| Molecular profiling | EV-associated proteins, phosphoproteins, RNA and targeted signaling markers, including p-MET and total MET. |
| Functional assays | Enzyme activity, membrane accessibility, inhibitor response, protease protection and recipient-cell effects. |
| Purity and identity | EV marker panels plus assessment of soluble proteins, lipoproteins and other non-vesicular co-isolates. |
| Study-ready analysis | Normalization, quality controls and clear reporting designed for discovery, validation and longitudinal studies. |
Who We Support
Clinical and translational research
Biomarker discovery, patient stratification and treatment-response monitoring.
Pharmaceutical and biotechnology teams
Pharmacodynamic readouts, target engagement and preclinical assay development.
Cell and gene therapy developers
EV product identity, purity, cargo, potency, stability and lot comparison.
Academic laboratories
Pilot studies, method development and access to specialized EV workflows.
Applications
CBT supports exploratory studies and translational programs in which EVs provide information that is difficult to obtain from bulk biofluids or conventional cell lysates.
- Disease biomarker discovery. Compare EV abundance, molecular cargo and functional activity across healthy, disease and treatment-response cohorts.
- Pharmacodynamic biomarkers. Measure pathway-specific changes such as phosphorylated and total receptor levels or EV-associated enzyme activity.
- Therapeutic EV development. Establish identity, purity, potency, stability and batch-comparability measurements for preclinical development.
- Drug and gene delivery research. Assess loading, recovery, targeting, uptake and biological response for engineered EV systems.
- Bioprocess and method development. Compare isolation, filtration, chromatography and analytical workflows using recovery and purity controls.
A Question-Led Workflow
- DefineClarify the sample, comparison, biological claim and decision the data must support.
- DesignSelect isolation, characterization, controls and normalization before samples are processed.
- AnalyzeGenerate physical, molecular and functional measurements using matched assay conditions.
- InterpretSeparate EV abundance, cargo, activity and membrane-accessibility effects.
- ReportDeliver methods, quality controls, limitations and study-ready results.
Controls That Strengthen the Conclusion
- EV-enriched and EV-depleted comparisons
- Particle, protein and source-volume normalization
- Matrix-matched fluorescence and inhibitor controls
- EV identity and non-vesicular contamination markers
- Clear limits on interpretation and clinical claims
Starting a Project
For an efficient first discussion, provide the sample type, available volume, number of samples, relevant clinical or experimental groups, target markers, intended comparison and any storage or handling constraints.
Research Use Only CBT services are intended for research use. Therapeutic or diagnostic claims require appropriate analytical validation, independent clinical validation and applicable regulatory review.