Consumer Products / Industrial Chemicals
Human-relevant safety testing for skin, eye and inhalation exposure
CBT supports consumer product and chemical companies with non-animal testing for irritation, corrosion and inhalation toxicity, including aerosols, sprays and volatile compounds.
Applications
Where we help
Our platforms use 3D reconstructed human tissues that closely mimic in vivo physiology, enabling reliable and predictive safety assessment without animal testing.
- Skin, eye and inhalation exposure
- Aerosols, sprays and volatile compounds
- Occupational/
consumer exposure - Irritation/
corrosion - Product safety
- Formulation screening
- Human-relevant models
Our Capabilities
3D reconstructed human tissue models
Inhalation Toxicity (In Vitro)
Using 3D reconstructed human airway / respiratory tissues:
- Aerosols, sprays, and volatile compounds
- Respiratory exposure assessment
Scientific basis
Air–liquid interface cultures of bronchial epithelial cells mimic respiratory tract architecture and exposure conditions, enabling realistic aerosol and vapor testing.
3D Human Skin Models
Using 3D reconstructed human epidermis (RhE):
- Skin irritation and corrosion
- Barrier function and toxicity
- Repeat exposure studies
Scientific basis
Multi-layered keratinocyte cultures replicate the stratum corneum barrier, enabling accurate prediction of irritation and corrosion responses.
OECD Guidelines
- Skin Irritation: OECD TG 439
- Skin Corrosion: OECD TG 431
Eye irritation
Using 3D reconstructed human corneal epithelium (RhCE):
- Eye irritation assessment using validated in vitro systems
- Alternatives to animal testing
Scientific basis
Stratified corneal epithelial cells reproduce ocular surface responses, allowing prediction of irritation potential through viability and barrier disruption endpoints.
OECD Guideline and Methods
- Eye Irritation: OECD TG 492
Methods
EpiOcular™ Eye Irritation Test (OCL-200-EIT)
For assessment of eye irritation
Sub-Draize Mildness Testing (MTT ET-50)
For Use with EpiOcular™ Tissue to determine ET-50
Scientific Validation
Our in vitro models are supported by data presented at the Society of Toxicology (SOT), demonstrating their predictive performance and applicability to real-world safety assessment.
OECD Status: Studies conducted using advanced, scientifically validated in vitro approaches
Skin & ocular models
Validated using OECD TG 439 and TG 492 with demonstrated reliability in irritation classification
Inhalation models
Novel approach developed to correlate in vitro airway exposure with real-world occupational inhalation scenarios
Robust assay performance
Validated methods addressing common challenges such as test article interference and assay sensitivity