Agrochemical / Crop Protection
Safety studies for agrochemicals and pesticides
CBT supports agrochemical and crop protection companies with mammalian toxicology and dermal, ocular and inhalation exposure studies on active ingredients and formulations.
Applications
Where we help
CBT runs studies for agrochemicals and pesticides according to OECD Guidelines and following EPA GLPs.
- Crop protection
- Active ingredients and formulations
- Mammalian toxicology
- Dermal/
ocular/ inhalation exposure - Formulation testing
- Regulatory data needs
- Human-relevant/
alternative methods where appropriate
Our Capabilities
3D reconstructed human tissue models
3D Human Skin Models
Using 3D reconstructed human epidermis (RhE):
- Skin irritation and corrosion
- Barrier function and toxicity
- Repeat exposure studies
Scientific basis
Multi-layered keratinocyte cultures replicate the stratum corneum barrier, enabling accurate prediction of irritation and corrosion responses.
OECD Guidelines
- Skin Irritation: OECD TG 439
- Skin Corrosion: OECD TG 431
Eye irritation
Using 3D reconstructed human corneal epithelium (RhCE):
- Eye irritation assessment using validated in vitro systems
- Alternatives to animal testing
Scientific basis
Stratified corneal epithelial cells reproduce ocular surface responses, allowing prediction of irritation potential through viability and barrier disruption endpoints.
OECD Guideline and Methods
- Eye Irritation: OECD TG 492
Methods
EpiOcular™ Eye Irritation Test (OCL-200-EIT)
For assessment of eye irritation
Sub-Draize Mildness Testing (MTT ET-50)
For Use with EpiOcular™ Tissue to determine ET-50
Inhalation Toxicity (In Vitro)
Using 3D reconstructed human airway / respiratory tissues:
- Aerosols, sprays, and volatile compounds
- Respiratory exposure assessment
Scientific basis
Air–liquid interface cultures of bronchial epithelial cells mimic respiratory tract architecture and exposure conditions, enabling realistic aerosol and vapor testing.